Roger M Mason Selected Research

Diabetic Nephropathies (Diabetic Nephropathy)

9/2012	Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.
6/2009	Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?
7/2005	Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2.
2/2005	Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA.
5/2003	Extracellular matrix metabolism in diabetic nephropathy.
3/2003	CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells.
10/2002	Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy.
3/2002	Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.

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Roger M Mason Research Topics

Disease

8	Fibrosis (Cirrhosis) 02/2013 - 01/2004
8	Diabetic Nephropathies (Diabetic Nephropathy) 09/2012 - 03/2002
3	Hypertrophy 02/2013 - 10/2002
2	Chronic Renal Insufficiency 02/2013 - 01/2006
1	Hyperglycemia 09/2012
1	Cicatrix (Scar) 06/2011
1	Renal Insufficiency (Renal Failure) 01/2006
1	Infections 07/2005
1	Knee Osteoarthritis 12/2003
1	Osteoarthritis 12/2003
1	Kidney Diseases (Kidney Disease) 03/2002

Drug/Important Bio-Agent (IBA)

6	Transforming Growth Factor beta (TGF-beta)IBA 01/2006 - 03/2002
5	Connective Tissue Growth FactorIBA 02/2013 - 10/2002
2	aristolochic acid I (aristolochic acid)IBA 09/2011 - 06/2011
2	Collagen Type I (Type I Collagen)IBA 09/2011 - 06/2011
2	Extracellular Matrix ProteinsIBA 01/2004 - 05/2003
1	Small Interfering RNA (siRNA)IBA 09/2012
1	Phosphotransferases (Kinase)IBA 09/2012
1	Proteins (Proteins, Gene)FDA Link 09/2012
1	trkA ReceptorIBA 09/2012
1	alpha2 Subunit Collagen Type IIBA 09/2011
1	CollagenIBA 06/2011
1	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2011
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2006
1	Bone Morphogenetic Protein 7IBA 01/2006
1	CholesterolIBA 01/2006
1	Cadherins (E-Cadherin)IBA 07/2005
1	A-factor (Streptomyces)IBA 02/2005
1	CytokinesIBA 01/2004
1	Interleukin-1beta (Interleukin 1 beta)IBA 12/2003
1	Matrix Metalloproteinase 3 (Stromelysin 1)IBA 12/2003
1	EnzymesIBA 12/2003
1	IceIBA 12/2003
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 12/2003
1	Fibronectins (Fibronectin)IBA 03/2003
1	Glucose (Dextrose)FDA LinkGeneric 03/2003
1	Antisense OligonucleotidesIBA 10/2002

Therapy/Procedure

1	Therapeutics 02/2013
1	Meniscectomy 12/2003